조골세포에서 Pleiotrophin(PTN)의 발현에 대한 연구
Pleiotrophin (PTN) expression in osteoblastic cells
김병렬, 이의석, 장현석, 임재석, 권종진, 전상호, 김영진,
소속 상세정보
김병렬 ( Kim Byeong-Yol ) - 고려대학교 의과대학 구강악안면외과학교실
이의석 ( Lee Eui-Seok ) - 고려대학교 구로병원 치과 구강악안면외과학교실
장현석 ( Jang Hyun-Suk ) - 고려대학교 구로병원 치과 구강악안면외과학교실
임재석 ( Rim Jae-Suk ) - 고려대학교 구로병원 치과 구강악안면외과학교실
권종진 ( Kwon Jong-Jin ) - 고려대학교 의과대학 구강악안면외과학교실
전상호 ( Jun Sang-Ho ) - 고려대학교 의과대학 구강악안면외과학교실
김영진 ( Kim Young-Jin ) - 고려대학교 의과대학 구강악안면외과학교실
KMID : 0360120070290060494
Abstract
Pleiotrophin or osteoblast-specific factor 1(OSF-1) is a growth-associated protein present in bone matrix. This study was designed to study pleiotrophin expression in osteoblastic cells. Pleiotrophin was expressed by osteoblast-like cell line. Pleiotrophin expression increased following the proliferative phase and was minimal at the terminal phases of the induced differentiation of cultured MC3T3-E1 cells. Pleiotrophin expression represents another autocrine factor that may contribute to the physiologic control of induced bone formation. In this study, induced osteogenesis will be examined in the context of the osteoblast expression of and regulation by PTN. I hypothesized that PDGF-BB stimulation of PTN expression represents an important paracrine signal during the induced osteogenesis associated with periodontal and implant surgeries. The possible mediation by PTN of anabolic effects attributed to PDGF-BB stimulation was examined in cell culture models of osteoblast differentiation. These studies will contribute fundamental insights to osteoblast biology and insights regarding the potential use of factors such as PTN in the clinical environment.
키워드
Pleiotrophin; Osteoblasts; Cell culture; Differentiation; Osteogenesis; Bone matrix
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